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Your Position: Home > Protein > CD4 > CD4-C5256

Rhesus macaque CD4 Protein, Fc Tag (MALS verified)

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  • Synonym
    CD4,CD4mut,LEU3
  • Source
    Rhesus macaque CD4, Fc Tag (CD4-C5256) is expressed from human 293 cells (HEK293). It contains AA Lys 26 - Trp 390 (Accession # G7N5T8).
    Predicted N-terminus: Lys 26
  • Molecular Characterization
    Online(Lys 26 - Trp 390) G7N5T8

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 67.0 kDa. The protein migrates as 67-85 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Rhesus macaque CD4, Fc Tag (Cat. No. CD4-C5256) SDS-PAGE gel

Rhesus macaque CD4, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Rhesus macaque CD4, Fc Tag (Cat. No. ) MALS images

The purity of Rhesus macaque CD4, Fc Tag(Cat. No. CD4-C5256) is more than 90% and the molecular weight of this protein is around 145-155 kDa verified by SEC-MALS.

Bioactivity-ELISA
Rhesus macaque CD4, Fc TagRhesus macaque CD4, Fc Tag (Cat. No. CD4-C5256) ELISA bioactivity

Immobilized Rhesus macaque CD4, Fc Tag (Cat. No. CD4-C5256) at 1 μg/mL (100 μL/well) can bind Ibalizumab with a linear range of 0.4-25 ng/mL (QC tested).

Rhesus macaque CD4, Fc TagRhesus macaque CD4, Fc Tag (Cat. No. CD4-C5256) ELISA bioactivity

Immobilized HIV-1 [HIV-1/Clade C (16055)] GP120, His Tag (Cat. No. GP5-V15224) at 10 μg/mL (100 μL/well) can bind Rhesus macaque CD4, Fc Tag (Cat. No. CD4-C5256)) with a linear range of 0.04-0.31 μg/mL (Routinely tested).

  • Background
    T-cell surface glycoprotein CD4 is also known as T-cell surface antigen T4/Leu-3. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is accessory protein for MHC class-II antigen/T-cell receptor interaction. CD4 induces the aggregation of lipid rafts. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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