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Human PTP4A2 / PRL-2 Protein, GST Tag  pdf  pdf  pdf


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Synonym

PTP4A2,PRL2,PTPCAAX2,HU-PP-1,OV-1,HMT,HNMT-S1,HNMT-S2

Source

Recombinant Human PTP4A2 /PRL-2 Protein,N-GST Tag (rh PTP4A2 / PRL-2, GST Tag) Asn 2 - Gln 167 (Accession # AAH70182) was produced in E.coli cells at ACROBiosystems.

Molecular Characterization

rh PTP4A2 / PRL-2, GST Tag is fused with a GST tag at the N-terminus, and has a calculated MW of 45.9 kDa. The predicted N-terminus is Met. DTT-reduced Protein migrates as 46 kDa in SDS-PAGE .

Endotoxin

Less than 1.0 EU per μg of the rh PTP4A2 / PRL-2, GST Tag by the LAL method.

Purity

>92% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM HEPES, 150 mM NaCl, pH7.5 . Normally Mannitol or Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).

 

SDS-PAGE


Recombinant Human PTP4A2 /PRL-2 Protein,N-GST Tag
The purity of rh PTP4A2 / PRL-2, GST Tag was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
 
 

Background

Protein tyrosine phosphatase type IVA 2 (PTP4A2),a member of the protein-tyrosine phosphatase family, is also known as Protein-tyrosine phosphatase 4a2, Protein-tyrosine phosphatase of regenerating liver 2 (PRL-2), PRL2 and PTPCAAX2,which is ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus and over expressed in prostate tumor tissue. PTP4A2 contains one tyrosine-protein phosphatase domain. In contrast to PTP4A1 and PTP4A3, PTP4A2 does not interact with tubulin but RABGGTB.PTP4A2 stimulates progression from G1 into S phase during mitosis and promotes tumors. PTP4A2 can also inhibit geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.The acticity of PTP4A2 is inhibited by sodium orthovanadate and pentamidine.

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References

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