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Human PTP4A2 / PRL-2 Protein, GST Tag  pdf  pdf  pdf


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PT2-H513x-100ug
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Synonym

PTP4A2,PRL2,PTPCAAX2,HU-PP-1,OV-1,HMT,HNMT-S1,HNMT-S2

Source

Human PTP4A2, GST Tag (PT2-H513x) is expressed from E.coli cells. It contains AA Asn 2 - Gln 167 (Accession # AAH70182).

Predicted N-terminus: Met

Molecular Characterization

GST
PTP4A2(Asn 2 - Gln 167)AAH70182

This protein carries a GST tag at the N-terminus.

The protein has a calculated MW of 45.9 kDa. The protein migrates as 46 kDa under reducing (R) condition (SDS-PAGE).

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>92% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM HEPES, 150 mM NaCl, pH7.5 . Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss is observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

SDS-PAGE

Human PTP4A2, GST Tag (Cat. No. PT2-H513x) SDS-PAGE gel

Human PTP4A2, GST Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%.

 

Background

Protein tyrosine phosphatase type IVA 2 (PTP4A2),a member of the protein-tyrosine phosphatase family, is also known as Protein-tyrosine phosphatase 4a2, Protein-tyrosine phosphatase of regenerating liver 2 (PRL-2), PRL2 and PTPCAAX2,which is ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus and over expressed in prostate tumor tissue. PTP4A2 contains one tyrosine-protein phosphatase domain. In contrast to PTP4A1 and PTP4A3, PTP4A2 does not interact with tubulin but RABGGTB.PTP4A2 stimulates progression from G1 into S phase during mitosis and promotes tumors. PTP4A2 can also inhibit geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.The acticity of PTP4A2 is inhibited by sodium orthovanadate and pentamidine.

References

Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.


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