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Human BMP-2 Protein, Tag Free  pdf  pdf  pdf


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BM2-H4117-20ug
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Synonym

BMP2,BMP2A

Source

Human BMP-2, Tag Free (BM2-H4117) is expressed from E.coli cells. It contains AA Gln 283 - Arg 396 (Accession # NP_001191).

Predicted N-terminus: Met

Molecular Characterization

BMP-2(Gln 283 - Arg 396)NP_001191

This protein carries no "tag".

The protein has a calculated MW of 13 kDa. The protein migrates as 13 kDa under reducing (R) condition and 24 kDa under non-reducing (NR) condition on SDS-PAGE gel.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

 

Purity

>92% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 0.1M acetic acid, pH2.0. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss is observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

SDS-PAGE

Human BMP-2, Tag Free (Cat. No. BM2-H4117) SDS-PAGE gel

The purity of rhBMP2 was determined by SDS-PAGE of reduced (R) and non-reduced (NR) rhBMP2 and staining overnight with Coomassie Blue.

 

Background

Human bone morphogenetic protein 2 (BMP2) is also known as human BMP-2, BMP-2, BMP2, BMP 2, h-BMP-2, rh-BMP-2, recombinant human BMP-2, recombinant BMP-2, BMP, is a member of the BMP subgroup belonging to the TGF-b superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. As implied by its name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP2 has been demonstrated to potently induce osteoblast differentiation in a variety of cell types, and induce apoptosis in human myeloma cell lines as a novel function.

References

Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.