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Human Vasorin / VASN Protein  pdf  pdf  pdf


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Synonym

VASN,SLITL2,Vasorin

Source

Recombinant Human VASN /Vasorin Protein (rh VASN / Vasorin) Cys 24 - Pro 575 (Accession # AAH68575) was produced in human 293 cells (HEK293) at ACROBiosystems.

Molecular Characterization

rh VASN / Vasorin is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 61.6 kDa. The predicted N-terminus is Cys 24. DTT-reduced Protein migrates as 80-100 kDa in SDS-PAGE due to glycosylation.

Endotoxin

Less than 1.0 EU per μg of the rh VASN / Vasorin by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).

 

SDS-PAGE


Recombinant Human VASN /Vasorin Protein
The purity of rh VASN / Vasorin was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
 
 

Background

Vasorin (VASN),a single-pass type I membrane protein, is also known as protein slit-like 2 and SLITL2, which contains one EGF-like domain, ten LRR (leucine-rich) repeats, one LRRCT domain and one LRRNT domain. VASN is expressed at highest levels in aorta, at intermediate levels in kidney and placenta and at lowest levels in brain, heart, liver, lung and skeletal muscle. VASN can interact selectively and non-covalently with TGF-beta, transform growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. In general, VASN may act as an inhibitor of TGF-beta signaling.

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References

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