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Human SBDS Protein  pdf  pdf  pdf


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SBS-H5141-100ug
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SBS-H5141-1mg
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Synonym

SBDS,CGI-97

Source

Human SBDS, His Tag (SBS-H5141) is expressed from E.coli cells. It contains AA Ser 2 - Glu 250 (Accession # AAH65700).

Predicted N-terminus: Met

Molecular Characterization

Poly-his
SBDS(Ser 2 - Glu 250)AAH65700

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 30 kDa. The protein migrates as 30-33 kDa under reducing (R) condition (SDS-PAGE).

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>98% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss is observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

SDS-PAGE

Human SBDS, His Tag (Cat. No. SBS-H5141) SDS-PAGE gel

Human SBDS, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 98%.

 

Background

Shwachman-Bodian-Diamond syndrome protein (SBDS),a member of the SDO1/SBDS family, is also known as ribosome maturation protein SBDS. SBDS is required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, SBDS triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby SBDS can activate ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. SBDS is also required for normal levels of protein synthesis. Furthermore, SBDS may play a role in cellular stress resistance.,response to DNA damage and cell proliferation.

References

Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.


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