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Human SBDS Protein  pdf  pdf  pdf


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Synonym

SBDS,CGI-97

Source

Recombinant Human SBDS Protein (rh SBDS) Ser 2 - Glu 250 (Accession # AAH65700) was produced in E.coli cells at ACROBiosystems.

Molecular Characterization

rh SBDS is fused with a polyhistidine tag at the N-terminus, and has a calculated MW of 30 kDa. The predicted N-terminus is Met. DTT-reduced Protein migrates as 30-33 kDa in SDS-PAGE .

Endotoxin

Less than 1.0 EU per μg of the rh SBDS by the LAL method.

Purity

>98% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).

 

SDS-PAGE


Recombinant Human SBDS  Protein
The purity of rh SBDS was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
 
 

Background

Shwachman-Bodian-Diamond syndrome protein (SBDS),a member of the SDO1/SBDS family, is also known as ribosome maturation protein SBDS. SBDS is required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, SBDS triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby SBDS can activate ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. SBDS is also required for normal levels of protein synthesis. Furthermore, SBDS may play a role in cellular stress resistance.,response to DNA damage and cell proliferation.

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References

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