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Human SUMO1 Protein  pdf  pdf  pdf


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SU1-H5144-200ug
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SU1-H5144-1mg
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Synonym

SUMO1,SMT3C,UBL1,Sentrin,GMP1

Source

Human SUMO1, His Tag (SU1-H5144) is expressed from E.coli cells. It contains AA Met 1 - Val 101 (Accession # AAH66306).

Predicted N-terminus: Met

Molecular Characterization

Poly-his
SUMO1(Met 1 - Val 101)AAH66306

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 12.4 kDa. The protein migrates as 20 kDa under reducing (R) condition (SDS-PAGE).

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH8.0. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss is observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

SDS-PAGE

Human SUMO1, His Tag (Cat. No. SU1-H5144) SDS-PAGE gel

Human SUMO1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

 

Background

Small ubiquitin-related modifier 1 (SUMO1),a member of the ubiquitin family and SUMO subfamily, is also known as GAP-modifying protein 1 (GMP1), SMT3 homolog 3, ubiquitin-homology domain protein PIC1 and ubiquitin-like protein UBL1,which contains one ubiquitin-like domain. Cleavage of precursor form by SENP1 or SENP2 is necessary for the function of SUMO1. Polymeric SUMO1 chains undergo polyubiquitination by RNF4. SUMO1 may also regulate a network of genes involved in palate development.SUMO1 plays an important role in modulation of NOX activity required for ROS generation.

References

Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.


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