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Human PSME2 / PA28b Protein  pdf  pdf  pdf


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PS2-H5143-100ug
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Synonym

PSME2,PA28beta,REG-beta

Source

Human PSME2, His Tag (PS2-H5143) is expressed from E.coli cells. It contains AA Ala 2 - Tyr 239 (Accession # AAH04368).

Predicted N-terminus: Met

Molecular Characterization

Poly-his
PSME2(Ala 2 - Tyr 239)AAH04368

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 28.2 kDa. The protein migrates as 31 kDa under reducing (R) condition (SDS-PAGE).

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH8.0. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss is observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

SDS-PAGE

Human PSME2, His Tag (Cat. No. PS2-H5143) SDS-PAGE gel

Human PSME2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

 

Background

Proteasome activator complex subunit 2 (PSME2), a member of the PA28 family, is also known as 11S regulator complex subunit beta (REG-beta), activator of multicatalytic protease subunit 2 and proteasome activator 28 subunit beta (PA28b). PSME2 can form heterodimer with PSME1. PSME2 is implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 (PSME2) activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

References

Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.


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