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Human PSME2 / PA28b Protein  pdf  pdf  pdf


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Synonym

PSME2,PA28beta,REG-beta

Source

Recombinant Human PSME2 /PA28b Protein (rh PSME2 / PA28b) Ala 2 - Tyr 239 (Accession # AAH04368) was produced in E.coli cells at ACROBiosystems.

Molecular Characterization

rh PSME2 / PA28b is fused with a polyhistidine tag at the N-terminus, and has a calculated MW of 28.2 kDa. The predicted N-terminus is Met. DTT-reduced Protein migrates as 31 kDa in SDS-PAGE .

Endotoxin

Less than 1.0 EU per μg of the rh PSME2 / PA28b by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM Tris,150 mM Nacl,pH8.0. Normally Mannitol or Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).

 

SDS-PAGE


Recombinant Human PSME2 /PA28b Protein
The purity of rh PSME2 / PA28b was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
 
 

Background

Proteasome activator complex subunit 2 (PSME2), a member of the PA28 family, is also known as 11S regulator complex subunit beta (REG-beta), activator of multicatalytic protease subunit 2 and proteasome activator 28 subunit beta (PA28b). PSME2 can form heterodimer with PSME1. PSME2 is implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 (PSME2) activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

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References

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