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Human SOD2 / Mn-SOD Protein  pdf  pdf  pdf


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Synonym

SOD2,IPOB,MNSOD

Source

Recombinant Human SOD2 /Mn-SOD Protein (rh SOD2 / Mn-SOD) Lys 25 - Lys 222 (Accession # AAH12423) was produced in E.coli cells at ACROBiosystems.

Molecular Characterization

rh SOD2 / Mn-SOD is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 23.2 kDa. The predicted N-terminus is Met. DTT-reduced Protein migrates as 27 kDa in SDS-PAGE .

Endotoxin

Less than 1.0 EU per μg of the rh SOD2 / Mn-SOD by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).

 

SDS-PAGE


Recombinant Human SOD2 /Mn-SOD Protein
The purity of rh SOD2 / Mn-SOD was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
 
 

Background

Superoxide dismutase [Mn], mitochondrial (SOD2),a member of the iron/manganese superoxide dismutase family, can form a homotetramer and bind one manganese ion per subunit. The expression of SOD2 is regulated by KRIT1. Mutations in SOD2 gene have been associated with idiopathic cardiomyopathy (IDC), sporadic motor neuron disease, and cancer. Furthermore, Mn-SOD (SOD2) activity is essential to achieve optimal training-induced protection against both ischemia/reperfusion(IR)-induced cardiac arrhythmias and infarction.

Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.


References

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