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Human NME1 / NDKA / NM23-H1 Protein  pdf  pdf  pdf


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Synonym

NME1,NDP kinase A,NDPA,GAAD,NM23-H1

Source

Recombinant Human NME1 /NDKA Protein (rh NME1 / NDKA) Ala 2 - Glu 152 (Accession # AAH00293) was produced in E.coli cells at ACROBiosystems.

Molecular Characterization

rh NME1 / NDKA is fused with a polyhistidine tag at the N-terminus, and has a calculated MW of 18 kDa. The predicted N-terminus is Met. DTT-reduced Protein migrates as 21 kDa in SDS-PAGE .

Endotoxin

Less than 1.0 EU per μg of the rh NME1 / NDKA by the LAL method.

Purity

>98% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).

 

SDS-PAGE


Recombinant Human NME1 /NDKA Protein
The purity of rh NME1 / NDKA was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
 
 

Background

Nucleoside diphosphate kinase A, a member of the NDK family, is also known as NME1, NDP kinase A (NDPA), granzyme A-activated DNase (GAAD), metastasis inhibition factor nm23 (NM23-H1) and tumor metastatic process-associated protein. NME1 plays a major role in the synthesis of nucleoside triphosphates other than ATP. NME1 is also involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Furthermore, NME1 is required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, NME1 works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.

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References

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