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Human DLL1 / Delta1 Protein  pdf  pdf  pdf


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Synonym

DLL1,Delta1,H-Delta-1

Source

Human DLL1 / Delta1 Protein, Gln 18 - Gly 540 (Accession # NP_005609) was produced in human 293 cells (HEK293) at ACROBiosystems.

Molecular Characterization

DLL1 (Gln 18-Gly 540)NP_005609

polyhistidine

Human DLL1, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 58.4 kDa. The predicted N-terminus is Gln 18. The reducing (R) protein migrates as 66 kDa in SDS-PAGE due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH 7.5. Normally Trehalose is added as protectant before lyophilization.

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Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).

 

SDS-PAGE


Human DLL1 / Delta1 Protein
Human DLL1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
 
 

Background

Delta-like protein 1 (DLL1) is also known as Drosophila Delta homolog 1 (Delta1 or H-Delta-1), which contains one DSL domain and eight EGF-like domains. DLL1 is ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation. As for expression, DLL1 is expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney. Furthermore, DLL1 acts as a ligand for Notch receptors. Also, DLL1 can block the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.

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References

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