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Recombinant Human IL17 /IL17A Protein,Tag Free  pdf  pdf  pdf


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ILA-H5118-25ug
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Synonym

IL-17A, Interleukin-17A, CTLA-8, IL-17

Source

Human IL17 / IL17A Protein,Tag Free , Gly 24 - Ala 155 (Accession # Q16552) was produced in E.coli cells at ACROBiosystems.

Molecular Characterization

IL17 (Gly 24-Ala 155)Q16552

Human IL17A,Tag Free contains no "tag", and has a calculated MW of 15.1 kDa. The predicted N-terminus is Met. The reducing (R) protein migrates as 16 kDa in SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.

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Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).

 

SDS-PAGE

Human IL17A,Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity

Immobilized Human IL17 /IL17A,Tag Free (Catalog # ILA-H5118) at 2 μg/mL (100 μL/well ) can bind Human IL-17 RA, Fc Tag (Catalog # ILA-H5257) with a linear ranger of 0.3 - 5 ng/mL.

 
 

Background

Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

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References