TNFRSF25, DR3, APO3, DDR3, TNFRSF12, WSL, WSL1
Cynomolgus DR3 / TNFRSF25 Protein, Fc Tag (Cynomolgus DR3 / TNFRSF2, Fc Tag) Gln 20 - Gly 203 (Accession # G7NTB5) was produced in human 293 cells (HEK293) at ACROBiosystems.
Cynomolgus DR3 / TNFRSF2, Fc Tag is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 46.3 kDa. The predicted N-terminus is Gln 20. The reducing (R) protein migrates as 50 kDa in SDS-PAGE .
Less than 1.0 EU per μg of the Cynomolgus DR3 / TNFRSF2, Fc Tag by the LAL method.
>90% as determined by SDS-PAGE.
Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
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See Certificate of Analysis for reconstitution instructions and specific concentrations.
Avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).
Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) is also known as Apo-3, Death receptor 3 (DDR3 or DR3), Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor TRAMP, Lymphocyte-associated receptor of death, Apo-3, which is a member of the TNF-receptor superfamily. TNFRSF25 is a homodimer protein, which can Interact strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. TNFRSF25 is receptor for TNFSF12 / APO3L / TWEAK.
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