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Mouse LAG-3 / CD223 Protein  pdf  pdf  pdf


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LA3-M52H5-100ug
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Synonym

LAG3,CD223,FDC

Source

Mouse LAG-3, His Tag (LA3-M52H5) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Leu 442 (Accession # Q61790).

Predicted N-terminus: Gly 24

Molecular Characterization

LAG-3(Gly 24 - Leu 442)Q61790
Poly-his

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 47.1 kDa. The protein migrates as 55-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss is observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

SDS-PAGE

Mouse LAG-3, His Tag (Cat. No. LA3-M52H5) SDS-PAGE gel

Mouse LAG-3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

 

Background

Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. LAG3 /CD223 involved in lymphocyte activation. LAG3 /CD223 binds to HLA class-II antigens.

References

Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.


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