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Cynomolgus CRTAM Protein, Fc Tag  pdf  pdf  pdf


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Synonym

CRTAM

Source

Cynomolgus CRTAM Protein, Fc Tag (Cynomolgus CRTAM, Fc Tag) Ser 18 - Gly 287 (Accession # XP_005580021.1) was produced in human 293 cells (HEK293) at ACROBiosystems.

Molecular Characterization

Cynomolgus CRTAM, Fc Tag is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 56.6 kDa. The predicted N-terminus is Ser 18. The reducing (R) protein migrates as 85-95 kDa in SDS-PAGE .

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>90% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).

 

SDS-PAGE


Cynomolgus CRTAM Protein, Fc Tag
Cynomolgus CRTAM, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
 
 

Background

Class I-restricted T cell-associated molecule (CRTAM), a member of nectin family and the immunoglobulin superfamily, is also known as cytotoxic and regulatory T-cell molecule, which is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and surprisingly, in brain where it is highly expressed by Purkinje cells of the cerebellum. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions (3 - 5). IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production (3, 4). Furthermore, a role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed.

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References

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