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Your Position: Home > Protein > BTN3A1 > BT1-H5255

Human BTN3A1 / CD277 Protein, Fc Tag (MALS verified)

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  • Synonym
    BTN3A1,CD277,BTF5
  • Source
    Human BTN3A1, Fc Tag(BT1-H5255) is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Gly 254 (Accession # AAI21801 ).
    Predicted N-terminus: Gln 30
  • Molecular Characterization
    BTN3A1 Structure

    This protein carries a human IgG1 Fc tag at the C-terminus

    The protein has a calculated MW of 50.8 kDa. The protein migrates as 58-65 kDa under reducing (R) condition, and 120 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
BTN3A1 SDS-PAGE

Human BTN3A1, Fc Tag on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
BTN3A1 MALS images

The purity of Human BTN3A1, Fc Tag (Cat. No. BT1-H5255) is more than 90% and the molecular weight of this protein is around 95-115 kDa verified by SEC-MALS.

  • Background
    Butyrophilin subfamily 3 member A1 (BTN3A1) is also known as CD277 and BTF5, which belongs to the immunoglobulin superfamily and contains one B30.2/SPRY domain and two Ig-like V-type (immunoglobulin-like) domains. BTN3A1 plays a role in T-cell activation and in the adaptive immune response. Also, BTN3A1 regulates the proliferation of activated T-cells and the release of cytokines and IFNG by activated T-cells. Furthermore, BTN3A1 mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.
  • Clinical and Translational Updates

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  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:1 Details
  • Latest Research Phase:Phase 2 Clinical

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