Thymopoietin, TMPO, LAP2
Human Thymopoietin / TMPO Protein, Met 1 - Tyr 323 (Accession # NP_001027454) was produced in E.coli cells at ACROBiosystems.
Human TMPO, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 21.4 kDa. The predicted N-terminus is Met 1. The reducing (R) protein migrates as 22 kDa in SDS-PAGE.
Less than 1.0 EU per μg by the LAL method.
>95% as determined by SDS-PAGE.
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.
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See Certificate of Analysis for reconstitution instructions and specific concentrations.
Avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).
Lamina-associated polypeptide 2, isoforms beta/gamma (LAP2) is also known as thymopoietin (TMPO), isoforms beta/gamma (TP beta/gamma). The thymopoetin (TMPO) gene encodes three alternatively spliced mRNAs encoding proteins of 75 kDa (alpha), 51 kDa (beta) and 39 kDa (gamma) which are ubiquitously expressed in all cells. TMPO may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. Also, TMPO may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Furthermore, TMPO beta is a human homolog of the murine protein LAP2. Given the nuclear localization of the three TMPO isoforms, it is unlikely that these proteins play any role in CD90 induction.
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