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Human ANGPTL7 / CDT6 Protein  pdf  pdf  pdf


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AN7-H52H5-100ug
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Synonym

ANGPTL7,CDT6

Source

Human ANGPTL7, His Tag (AN7-H52H5) is expressed from human 293 cells (HEK293). It contains AA Gln 27 - Pro 346 (Accession # O43827-1).

Predicted N-terminus: Gln 27

Molecular Characterization

ANGPTL7(Gln 27 - Pro 346)O43827-1
Poly-his

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 39 kDa. The protein migrates as 38-40 kDa and 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>85% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss is observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

SDS-PAGE

Human ANGPTL7, His Tag (Cat. No. AN7-H52H5) SDS-PAGE gel

Human ANGPTL7, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 85%.

 

Bioactivity

Human ANGPTL7, His Tag (Cat. No. AN7-H52H5) ELISA bioactivity

Immobilized Human ANGPTL7, His Tag (Cat. No. AN7-H52H5) at 5 μg/mL (100 μL/well) can bind Human LILRB4, Fc Tag (Cat. No. LI4-H5259) with a linear range of 0.031-0.5 μg/mL (Routinely tested).

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Human ANGPTL7, His Tag (Cat. No. AN7-H52H5) ELISA bioactivity

Immobilized Human ANGPTL7, His Tag (Cat. No. AN7-H52H5) at 5 μg/mL (100 μL/well) can bind Human LILRB2, Fc Tag (Cat. No. CDD-H5259) with a linear range of 0.031-2 μg/mL (QC tested).

Request for protocol

Human ANGPTL7, His Tag (Cat. No. AN7-H52H5) ELISA bioactivity

Immobilized Human ANGPTL7, His Tag (Cat. No. AN7-H52H5) at 5 μg/mL (100 μL/well) can bind Human LILRA3, Fc Tag (Cat. No. LI3-H5256) with a linear range of 0.016-1 μg/mL (Routinely tested).

Request for protocol

 

Background

Angiopoietin-like 7 (ANGPTL7) is also known as Corneal-Derived Transcript 6 (CDT6), and is a secreted glycoprotein that is structurally related to the angiopoietins. It is expressed in the corneal stroma, trabecular meshwork, and sclera and is elevated in glaucoma aqueous humor. Recently, ANGPTL proteins, including ANGPTL-2, -3, -4, -5 and -7, are identified as growth factors in combination with SCF, Thrombopoietin, IGF-II and FGF acidic that enhance the expansion and engraftment of human and mouse hematopoietic stem cells.

References

Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.


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