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Human Cyclophilin B / PPIB Protein  pdf  pdf  pdf


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Synonym

PPIB,CYPB,PPIase B,CYP-S1

Source

Human Cyclophilin B / PPIB Protein (Human PPIB, His Tag) Asp 34 - Ala 212 (Accession # NP_000933) was produced in human 293 cells (HEK293) at ACROBiosystems.

Molecular Characterization

Human PPIB, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 20.7 kDa. The predicted N-terminus is Asp 34. DTT-reduced Protein migrates as 22 kDa in SDS-PAGE due to glycosylation.

Endotoxin

Less than 1.0 EU per μg of the Human PPIB, His Tag by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).

 

SDS-PAGE


Human Cyclophilin B /  PPIB Protein
The purity of Human PPIB, His Tag was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
 
 

Background

Peptidyl-prolyl cis-trans isomerase B (PPIB or PPIase B) is also known as Cyclophilin B (CYPB), Rotamase B, S-cyclophilin (SCYLP), is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum, which belongs to the cyclophilin-type PPIase family and PPIase B subfamily. PPIB / CYPB contains one PPIase cyclophilin-type domain. PPIases accelerate the folding of proteins and catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

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References

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