Human Cyclophilin B / PPIB Protein (Human PPIB, His Tag) Asp 34 - Ala 212 (Accession # NP_000933) was produced in human 293 cells (HEK293) at ACROBiosystems.
Human PPIB, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 20.7 kDa. The predicted N-terminus is Asp 34. DTT-reduced Protein migrates as 22 kDa in SDS-PAGE due to glycosylation.
Less than 1.0 EU per μg of the Human PPIB, His Tag by the LAL method.
>95% as determined by SDS-PAGE.
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
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See Certificate of Analysis for reconstitution instructions and specific concentrations.
Avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
Peptidyl-prolyl cis-trans isomerase B (PPIB or PPIase B) is also known as Cyclophilin B (CYPB), Rotamase B, S-cyclophilin (SCYLP), is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum, which belongs to the cyclophilin-type PPIase family and PPIase B subfamily. PPIB / CYPB contains one PPIase cyclophilin-type domain. PPIases accelerate the folding of proteins and catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
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