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Human Bcl-x / BCL2L1 Protein, GST Tag  pdf  pdf  pdf


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Synonym

BCL2L1, Bcl-XL, Bcl2-L-1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, bcl-xS

Source

Recombinant Human BCL2L1 /Bcl-XL Protein, N-GST Tag (rhBCL2L1, N-GST Tag) Met 1 - Arg 212 (Accession # AAH19307) was produced in E.coli cells at ACRObiosystems.

Molecular Characterization

rhBCL2L1, N-GST Tag, fused with GST tag at the N-terminus, has a calculated MW of 50.5 kDa. The predicted N-terminus is Met. DTT-reduced Protein migrates as 46 kDa.

Endotoxin

Less than 1.0 EU per μg of the rhBCL2L1, N-GST Tag by the LAL method.

Purity

>92% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 20 mM Tris, pH7.5 with 100 mM NaCl, 10 mM GSH. Normally Mannitol or Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).

 

SDS-PAGE


Recombinant Human BCL2L1 /Bcl-XL Protein, N-GST Tag
The purity of rhBCL2L1, N-GST Tag was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
 
 

Background

Bcl-2-like protein 1 (BCL2L1), is also known as Apoptosis regulator Bcl-X (Bcl-XL). BCL2L1 / Bcl-XL is a homodimer protein and belongs to the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a potent inhibitor of cell death. BCL2L1 Inhibits activation of caspases. BCL2L1 appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. BCL2L1 / Bcl-XL also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.

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