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Your Position: Home > Protein > TWEAK R > TNA-H526a

Human TWEAK R / TNFRSF12A Protein, Fc Tag

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  • Synonym
    TNFRSF12A,FGF-inducible 14,FN14,TweakR,CD266
  • Source
    Human TWEAK R, Fc Tag(TNA-H526a) is expressed from human 293 cells (HEK293). It contains AA Glu 28 - Trp 79 (Accession # AAH02718).
  • Molecular Characterization
    TWEAK R Structure

    This protein carries a human IgG1 Fc tag at the N-terminus

    The protein has a calculated MW of 32.5 kDa. The protein migrates as 32-45 kDa under reducing (R) condition, and 55-80 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
TWEAK R SDS-PAGE

Human TWEAK R, Fc Tag on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) is also known as Fibroblast growth factor-inducible immediate-early response protein 14 (FN14 or FGF-inducible 14), Tweak-receptor, CD antigen CD266. TNFRSF12A contains one TNFR-Cys repeat. TNFRSF12A is highly expressed in heart, placenta and kidney. TNFRSF12A is receptor for TNFSF12/TWEAK, and is weak inducer of apoptosis in some cell types. TNFRSF12A / FN14 promotes angiogenesis and the proliferation of endothelial cells.
  • Clinical and Translational Updates

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