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Human CNDP1 Protein  pdf  pdf  pdf


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Synonym

CNDP1,CN1,CPGL2

Source

Human CNDP1, His Tag (CN1-H5224) is expressed from human 293 cells (HEK293). It contains AA Ser 28 - His 508 (Accession # AAI17123).

Predicted N-terminus: Ser 28

Molecular Characterization

CNDP1(Ser 28 - His 508)AAI17123
Poly-his

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 54.7 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

 

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss is observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

SDS-PAGE

Human CNDP1, His Tag (Cat. No. CN1-H5224) SDS-PAGE gel

Human CNDP1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

 

Background

Beta-Ala-His dipeptidase is also known as Carnosine dipeptidase 1 (CNDP1), CNDP dipeptidase 1, Glutamate carboxypeptidase-like protein 2, Serum carnosinase, CPGL2, which belongs to the peptidase M20A family. CNDP1 is found in serum and adult nervous central system. CNDP1 preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine. The catalytic activity of CNDP1 is inhibited by the metal chelator 1,10-o-phenantrolin and the inhibitory concentration 50% (IC50) is 5 µM.

References

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