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Human Osteoprotegerin / TNFRSF11B Protein  pdf  pdf  pdf


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Synonym

TNFRSF11B,OCIF,OPG,Osteoprotegerin

Source

Human Osteoprotegerin / TNFRSF11B Protein (Human Osteoprotegerin, His Tag) Glu 22 - Leu 401 (Accession # NP_002537) was produced in human 293 cells (HEK293) at ACROBiosystems.

Molecular Characterization

Human Osteoprotegerin, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 44.4 kDa. The predicted N-terminus is Glu 22. The reducing (R) protein migrates as 55 kDa in SDS-PAGE due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).

 

SDS-PAGE


Human Osteoprotegerin / TNFRSF11B Protein
Human Osteoprotegerin, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
 
 

Background

Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG). TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

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References