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Human DcR3 / TNFRSF6B Protein, Fc Tag  pdf  pdf  pdf


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TNB-H5255-50ug
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3-4 Weeks
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Synonym

TNFRSF6B, DCR3, TR6, M68

Source

Recombinant Human TNFRSF6B /DcR3 Protein,C-Fc Tag,HEK293 expressed (rh TNFRSF6B / DcR3 Fc Chimera) Val 30 - His 300 (Accession # AAH17065) was produced in human 293 cells (HEK293) at ACROBiosystems.

Molecular Characterization

rh TNFRSF6B / DcR3 Fc Chimera is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 56.4 kDa. The predicted N-terminus is Val 30. DTT-reduced Protein migrates as 64 kDa in SDS-PAGE due to glycosylation.

Endotoxin

Less than 1.0 EU per μg of the rh TNFRSF6B / DcR3 Fc Chimera by the LAL method.

Purity

>85% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).

 

SDS-PAGE


Recombinant Human TNFRSF6B /DcR3 Protein,C-Fc Tag,HEK293 expressed
The purity of rh TNFRSF6B / DcR3 Fc Chimera was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
 
 

Background

Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) is also known as Decoy Receptor 3 (DcR3), Decoy receptor for Fas ligand and M68, which belongs to the tumor necrosis factor receptor superfamily. TNFRSF6 is a soluble protein which contains four TNFR-Cys repeats. Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain. TNFRSF6B acts as a decoy receptor that competes with death receptors for ligand binding. The protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A.

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References