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Human Transthyretin / Prealbumin Protein  pdf  pdf  pdf


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Synonym

Transthyretin,TTR,Prealbumin,TBPA,ATTR,PALB,CTS,CTS1,HsT2651

Source

Human Transthyretin / Prealbumin Protein (Human Transthyretin, His Tag) Gly 21 - Glu 147 (Accession # NP_000362) was produced in human 293 cells (HEK293) at ACROBiosystems.

Molecular Characterization

Human Transthyretin, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 14.6 kDa. The predicted N-terminus is Gly 21. The reducing (R) protein migrates as 19 kDa and 37kDa in SDS-PAGE due to the monomer and dimer respectively.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).

 

SDS-PAGE


Human Transthyretin / Prealbumin Protein
Human Transthyretin, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
 
 

Background

Transthyretin (TTR) is also known as Prealbumin, ATTR, TBPA, PALB, which belongs to the transthyretin family. Transthyretin / TTR is a serum and cerebrospinal fluid carrier of the thyroid hormone thyroxine (T4) and retinol-binding protein bound to retinol. In cerebrospinal fluid TTR is the primary carrier of T4. TTR also acts as a carrier of retinol (vitamin A) through its association with retinol-binding protein (RBP) in the blood and the CSF. Less than 1% of TTR's T4 binding sites are occupied in blood. TTR misfolding and aggregation is known to be associated with the amyloid diseases.

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References

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