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Human APCS / SAP / PTX2 Protein  pdf  pdf  pdf


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APS-H5229-100ug
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APS-H5229-1mg (500ug x 2)
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Synonym

PTX2,APCS,SAMP,SAP,Pentraxin 2

Source

Human APCS, His Tag (APS-H5229) is expressed from human 293 cells (HEK293). It contains AA His 20 - Val 223 (Accession # NP_001630).

Predicted N-terminus: His 20

Molecular Characterization

APCS(His 20 - Val 223)NP_001630
Poly-his

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 24 kDa. The protein migrates as 26 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH 7.5. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss is observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

SDS-PAGE

Human APCS, His Tag (Cat. No. APS-H5229) SDS-PAGE gel

Human APCS, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

 

Background

Serum amyloid P-component (SAP) is also known as Pentraxin 2 (PTX2), APCS, which belongs to the pentaxin family. SAP contains one pentaxin domain. PTX2 is a secreted homopentamer protein which is found in serum and urine. SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits. SAP can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. SAP may also function as a calcium-dependent lectin. SAP has certain sequence homology with C-reactive protein (CRP).

References

Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.


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