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Human Cathepsin D / CTSD Protein  pdf  pdf  pdf


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Synonym

CTSD, Cathepsin D, CPSD, CLN10

Source

Recombinant Human CTSD /Cathepsin D Protein (rh CTSD / Cathepsin D) Ser 19 - Leu 412 (Accession # NP_001900) was produced in human 293 cells (HEK293) at ACRObiosystems.

Molecular Characterization

rh CTSD / Cathepsin D, fused with polyhistidine tag at the C-terminus, has a calculated MW of 43.6 kDa. The predicted N-terminus is Ser 19. DTT-reduced Protein migrates as 45-55 kDa due to glycosylation.

Endotoxin

Less than 1.0 EU per μg of the rh CTSD / Cathepsin D by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM MES, pH 6.5 with 100 mM NaCl. Normally Mannitol or Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).

 

SDS-PAGE


Recombinant Human CTSD /Cathepsin D Protein
The purity of rh CTSD / Cathepsin D was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
 
 
 

Background

Cathepsin D is also known as CTSD, CPSD, which belongs to the peptidase A1 family. Cathepsin D can be cleaved into the following 2 chains: cathepsin D light chain and cathepsin D heavy chain, which is expressed in the aorta extrcellular space (at protein level). The catalytic activity of Cathepsin D is specificity similar to, but narrower than, that of pepsin A. Cathepsin D does not cleave the 4-Gln-|-His-5 bond in B chain of insulin. Cathepsin D involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.

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References

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