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Human Cathepsin D / CTSD Protein  pdf  pdf  pdf


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CTD-H5226-50ug
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Synonym

CTSD,Cathepsin D,CPSD,CLN10

Source

Human Cathepsin D, His Tag (CTD-H5226) is expressed from human 293 cells (HEK293). It contains AA Ser 19 - Leu 412 (Accession # NP_001900).

Predicted N-terminus: Ser 19

Molecular Characterization

Cathepsin D(Ser 19 - Leu 412)NP_001900
Poly-his

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 43.6 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM MES, pH 6.5 with 100 mM NaCl. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss is observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

SDS-PAGE

Human Cathepsin D, His Tag (Catalog # CTD-H5226) SDS-PAGE gel

Human Cathepsin D, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

 

Background

Cathepsin D is also known as CTSD, CPSD, which belongs to the peptidase A1 family. Cathepsin D can be cleaved into the following 2 chains: cathepsin D light chain and cathepsin D heavy chain, which is expressed in the aorta extrcellular space (at protein level). The catalytic activity of Cathepsin D is specificity similar to, but narrower than, that of pepsin A. Cathepsin D does not cleave the 4-Gln-|-His-5 bond in B chain of insulin. Cathepsin D involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.

References

Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.


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