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Human Kallikrein 13 / KLK-13 Protein  pdf  pdf  pdf


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Synonym

KLK13, KLKL4, KLK-13, Kallikrein-13

Source

Recombinant Human KLK13 /Kallikrein-13 Protein (rhKallikrein-13 /KLK13) Gly 18 - Ile 262 (Accession # AAH69334) was produced in human 293 cells (HEK293) at ACROBiosystems.

Molecular Characterization

rhKallikrein-13 /KLK13 is fused with 6×his tag at the C-terminus, and has a calculated MW of 28 kDa. The predicted N-terminus is Gly 18. DTT-reduced Protein migrates as 33-40 kDa in SDS-PAGE due to glycosylation.

Endotoxin

Less than 1.0 EU per μg of the rhKallikrein-13 /KLK13 by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 20mM MES, 150mM NaCl, pH 6.0. Normally Mannitol or Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).

 

SDS-PAGE


Recombinant Human KLK13 /Kallikrein-13 Protein
The purity of rhKallikrein-13 /KLK13 was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
 
 
 

Background

Kallikrein-13 (KLK13) is also known as Kallikrein-like protein 4 (KLK-L4), is a secreted protein, belongs to the peptidase S1 family and Kallikrein subfamily. KLK-13 contains one peptidase S1 domain. KLK13 is mainly expressed in prostate, breast, testis and salivary gland. KLK13 may be involved in the pathogenesis and / or progression of breast and ovary cancers, and is regarded as a novel cancer biomarker. In addition, KLK13 interacts and forms complexes with several serum protease inhibitors, such as alpha2-macroglobulin, and its expression is regulated by steroid hormones.

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References

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