Lipopolysaccharide-binding protein / LBP Molecule
Lipopolysaccharide-binding protein / LBP Molecule Synonym Name
Lipopolysaccharide-binding protein / LBP Protein Products
|Cat No||Species||Product Description|
|LBP-H52H5||Human||Human LBP /Lipopolysaccharide Protein|
Lipopolysaccharide-binding protein / LBP Molecule Background
Lipopolysaccharide-binding protein (LBP),a member of the BPI/LBP/Plunc superfamily, BPI/LBP family, is detected in blood serum. LBP plays a role in the innate immune response. Alao,LBP can bind to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and act as an affinity enhancer for CD14, facilitating its association with LPS. Furthermore, LBP is able to promote the release of cytokines in response to bacterial lipopolysaccharide.
- (1) Schumann R.R., et al., 1990, Science 249:1429-1431.
- (2) Hubacek J.A., et al., 1997, Biochem. Biophys. Res. Commun. 236:427-430.
- (3) Eckert J.K., et al., 2013, Immunity 39:647-660.