Glycoprotein / GP (virus) Molecule
Glycoprotein Molecule Synonym Name
Glycoprotein Protein Products
|Cat No||Species||Product Description|
|BEP-V5220||Ebolavirus||Recombinant Ebolavirus BDBV(subtype Bundibugyo,strain Uganda 2007) Small/secreted Glycoprotein (sGP)|
|BEP-V5221||Ebolavirus||Recombinant Ebolavirus (subtype Bundibugyo,strain Uganda 2007) Envelope Glycoprotein 1 (GP1)|
|CMB-V5255||HCMV||Recombinant HCMV Glycoprotein B (gB), Fc Tag|
|RSG-V5221||HRSV||Recombinant HRSV (A) Glycoprotein G|
|ZE5-V5220||Ebolavirus||Recombinant Ebolavirus EBOV (subtype Zaire,strain Kikwit-95) Envelope Glycoprotein 1 (GP1)|
|ZE5-V5221||Ebolavirus||Recombinant Ebolavirus EBOV (subtype Zaire,strain Kikwit-95) Envelope Glycoprotein (GP)|
Glycoprotein Molecule Background
EBOV encodes seven structural proteins: nucleoprotein (NP), polymerase cofactor (VP35), (VP40), GP, transcription activator (VP30), VP24, and RNA polymerase (L). GP protein contains 160-kDa envelope-attached glycoprotein (GP) and a 110 kDa secreted glycoprotein (sGP). GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. GP2 acts as a class I viral fusion protein. GP1,2 mediates endothelial cell activation and decreases endothelial barrier function. sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha.
- (1) Saeed M.F., et al., 2010, PLoS Pathog. 6:0-0.
- (2) Marzi A., et al., 2006, J. Virol. 80:6305-6317.
- (3) Chandran K., et al., 2005, Science 308:1643-1645.