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Browse By Molecule Name --->Glycoprotein / GP (virus) Molecule

Glycoprotein / GP (virus) Molecule  


Glycoprotein Molecule Synonym Name

Glycoprotein Protein Products

Cat No Species Product Description
BEP-V5220EbolavirusRecombinant Ebolavirus BDBV(subtype Bundibugyo,strain Uganda 2007) Small/secreted Glycoprotein (sGP)
BEP-V5221EbolavirusRecombinant Ebolavirus (subtype Bundibugyo,strain Uganda 2007) Envelope Glycoprotein 1 (GP1)
CMB-V5255HCMVRecombinant HCMV Glycoprotein B (gB), Fc Tag
RSG-V5221HRSVRecombinant HRSV (A) Glycoprotein G
ZE5-V5220EbolavirusRecombinant Ebolavirus EBOV (subtype Zaire,strain Kikwit-95) Envelope Glycoprotein 1 (GP1)
ZE5-V5221EbolavirusRecombinant Ebolavirus EBOV (subtype Zaire,strain Kikwit-95) Envelope Glycoprotein (GP)

Glycoprotein Molecule Background

EBOV encodes seven structural proteins: nucleoprotein (NP), polymerase cofactor (VP35), (VP40), GP, transcription activator (VP30), VP24, and RNA polymerase (L). GP protein contains 160-kDa envelope-attached glycoprotein (GP) and a 110 kDa secreted glycoprotein (sGP). GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. GP2 acts as a class I viral fusion protein. GP1,2 mediates endothelial cell activation and decreases endothelial barrier function. sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha.

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