IGFBP1 / PP12 Molecule
IGFBP-1 Molecule Synonym Name
IGFBP-1 Protein Products
|Cat No||Species||Product Description|
|IG1-C52H1||Rhesus macaque||Rhesus macaque IGFBP-1 Protein|
IGFBP-1 Molecule Background
Insulin-like growth factor-binding protein 1 (IGFBP1) is also known as placental protein 12 (PP12), which contains oneIGFBP N-terminal domain and one thyroglobulin type-1 domain. IGFBP1 can bindd both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of IGFBP1 can prolongd the half-life of the IGFs and alterd their interaction with cell surface receptors. Furthermore, IGFBP1 can promote cell migration. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
- (1) Lee Y.-L., et al., 1988, Mol. Endocrinol. 2:404-411.
- (2) Jones J.I., et al., 1993, J. Biol. Chem. 268:1125-1131.
- (3) Sala A., et al., 2005, J. Biol. Chem. 280:29812-29819.