ICOS / CD278 Molecule
ICOS / CD278 Molecule Synonym Name
ICOS / CD278 Protein Products
|Cat No||Species||Product Description|
|ICS-H5250||Human||Human ICOS / CD278 Protein, Fc Tag|
ICOS / CD278 Molecule Background
Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
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- (3) Beier K.C., et al., 2000, Eur. J. Immunol. 30:3707-3717.