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Browse By Molecule Name --->OX40 Ligand Molecule

OX40 Ligand Molecule  


OX40 Ligand Molecule Synonym Name

OX40L,TNFSF4,CD252,Glycoprotein Gp34,TXGP1

OX40 Ligand Protein Products

Cat No Species Product Description
OXL-H526xHumanHuman OX40 Ligand / TNFSF4 Protein, Fc Tag
OXL-H52Q8HumanHuman OX40 Ligand / TNFSF4 Protein (HPLC-verified)
OXL-M526xMouseMouse OX40 Ligand / TNFSF4 Protein, Fc Tag

OX40 Ligand Molecule Background

Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.

Reference

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