OX40 Ligand Molecule
OX40 Ligand Molecule Synonym Name
OX40 Ligand Protein Products
|Cat No||Species||Product Description|
|OXL-H526x||Human||Human OX40 Ligand / TNFSF4 Protein, Fc Tag|
|OXL-H52Q8||Human||Human OX40 Ligand / TNFSF4 Protein (HPLC-verified)|
|OXL-M526x||Mouse||Mouse OX40 Ligand / TNFSF4 Protein, Fc Tag|
OX40 Ligand Molecule Background
Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.
- (1) Compaan D.M., et al., 2006, Structure 14:1321-1330.
- (2) Maizels RM., et al., 2003, Nat. Rev. Immunol. 3 (9): 733–44.