UCH-L3 Molecule Synonym Name
UCHL3,Ubiquitin thioesterase L3
UCH-L3 Protein Products
|Cat No||Species||Product Description|
|UC3-H5141||Human||Human UCH-L3 / UCHL3 Protein|
UCH-L3 Molecule Background
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3), a member of peptidase C12 family, is also known as ubiquitin thioesterase L3. Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. UCH-L3 is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. UCH-L3 indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. It is also required for stress-response retinal, skeletal muscle and germ cell maintenance. Furthermore, UCH-L3 may be involved in working memory and can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.
- (1) Nam M.J., et al., 2003, Proteomics 3:2108-2115.
- (2) Setsuie R., et al., 2009, Neurochem. Int. 54:314-321.
- (3) Iphofer A., et al., 2012, ChemBioChem 13:1416-1420.