B18R Molecule Synonym Name
B18R Protein Products
|Cat No||Species||Product Description|
|B1R-H52H6||Vaccinia Virus||Vaccinia Virus B18R Protein|
B18R Molecule Background
B18R is a type I interferon (IFN)-binding protein and it is encoded by the B18R open reading frame in the WR (Western Reserve) strain of vaccinia virus, which contains two Ig-like C2-type domains and one Ig-like V-type domain. B18R exists in a soluble and a membrane-bound form. As a type I IFN receptor, B18R counteracts the antiviral effects of host IFN-alpha/beta. Also, B18R acts as a soluble IFN-alpha receptor and thus inhibits the interaction between host IFN-alpha and its receptor.
- (1) Alcami A., et al., 2000, J. Virol. 74:11230-11239.
- (2) Waibler Z., et al., 2009, J. Virol. 83:1563-1571.