4?1BB Ligand / TNFSF9 Molecule
4 1BB Ligand / TNFSF9 Molecule Synonym Name
4 1BB Ligand, TNFSF9, CD137L
4 1BB Ligand / TNFSF9 Protein Products
|Cat No||Species||Product Description|
|41L-H5257||Human||Human 4-1BB Ligand / TNFSF9 Protein, Fc Tag|
|41L-M5257||Mouse||Mouse 4-1BB Ligand / TNFSF9 Protein, Fc Tag|
4 1BB Ligand / TNFSF9 Molecule Background
Tumor necrosis factor ligand superfamily member 9 (4-1BBL) is also known as 4-1BB ligand, CD137L or TNFSF9, which is a cytokine that binds to TNFRSF9. 4-1BBL is the high affinity ligand of 4-1BB. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD). Furthermore, 4-1BBL may play a role in cognate interactions between T-cells and B-cells/macrophages. As for diseases, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.
- (1) Won E.Y., et al., 2010, J. Biol. Chem. 285:9202-9210.
- (2) Alderson M.R., et al., 1994, Eur. J. Immunol. 24:2219-2227.