DR3 / TNFRSF25 Molecule
DR3 / TNFRSF25 Molecule Synonym Name
DR3 / TNFRSF25 Protein Products
|Cat No||Species||Product Description|
|TN5-C5257||Cynomolgus||Cynomolgus DR3 / TNFRSF25 Protein, Fc Tag|
|TN5-H5258||Human||Human DR3 / TNFRSF25 Protein, Fc Tag|
DR3 / TNFRSF25 Molecule Background
Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) is also known as Apo-3, Death receptor 3 (DDR3 or DR3), Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor TRAMP, Lymphocyte-associated receptor of death, Apo-3, which is a member of the TNF-receptor superfamily. TNFRSF25 is a homodimer protein, which can Interact strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. TNFRSF25 is receptor for TNFSF12 / APO3L / TWEAK.
- (1) Kitson J., et al., 1996, Nature 384:372-375.
- (2) Bodmer J.-L., et al., 1997, Immunity 6:79-88.
- (3) Marsters S.A., et al., 1996, Curr. Biol. 6:1669-1676.