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Integrin alpha V beta 6 / ITGAVB6 Molecule  


Integrin alpha V beta 6 / ITGAVB6 Molecule Synonym Name

Integrin alpha V beta 6,ITGAV&ITGB6

Integrin alpha V beta 6 / ITGAVB6 Protein Products

Cat No Species Product Description
IT6-H52E1HumanHuman Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein

Integrin alpha V beta 6 / ITGAVB6 Molecule Background

Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency?associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.

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