B7-H3 / CD276 Molecule
B7-H3 / CD276 Molecule Synonym Name
B7-H3,CD276,B7 homolog 3
B7-H3 / CD276 Protein Products
|Cat No||Species||Product Description|
|B73-H5253||Human||Human B7-H3 / CD276 Protein, Fc Tag|
|B73-H52E2||Human||Human B7-H3 / CD276 Protein|
|B73-M5255||Mouse||Mouse B7-H3 / CD276 Protein, Fc Tag|
|B73-M52H4||Mouse||Mouse B7-H3 / CD276 Protein|
B7-H3 / CD276 Molecule Background
B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.
- (1) Chapoval A.I., et al., 2001, Nat. Immunol. 2:269-274.
- (2) Castriconi R., et al., 2004, Proc. Natl. Acad. Sci. U.S.A. 101:12640-12645.
- (3) Wang L., et al., 2005, Eur. J. Immunol. 35:428-438.