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Integrin alpha V beta 3 / ITGAVB3 Molecule  


Integrin alpha V beta 3 / ITGAVB3 Molecule Synonym Name

Integrin alpha V beta 3,ITGAV&ITGB3

Integrin alpha V beta 3 / ITGAVB3 Protein Products

Cat No Species Product Description
IT3-H52E3HumanHuman Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein

Integrin alpha V beta 3 / ITGAVB3 Molecule Background

Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Also, Integrin alpha-V/beta-3 acts as a receptor for herpes virus 8/HHV-8, coxsackievirus A9, Hantaan virus, cytomegalovirus/HHV-5, human metapneumovirus, human parechovirus 1 and west nile virus. Furthermore, in case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

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