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Nectin-2 / CD112 Molecule  


Nectin-2 / CD112 Molecule Synonym Name

CD112,Nectin-2,PVRL2

Nectin-2 / CD112 Protein Products

Cat No Species Product Description
PV2-H5253HumanHuman Nectin-2 / CD112 Protein, Fc Tag
PV2-H52E2HumanHuman Nectin-2 / CD112 Protein

Nectin-2 / CD112 Molecule Background

Poliovirus receptor-related 2 (PVRL2) is also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), which is a human plasma membrane glycoprotein. PVRL2 is one of the plasma membrane components of adherens junctions. PVRL2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Also, PVRL2 binds with low affinity to TIGIT. Furthermore, PVRL2 acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).

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