Galectin-9 / LGALS9 Molecule
Galectin-9 / LGALS9 Molecule Synonym Name
Galectin-9 / LGALS9 Protein Products
|Cat No||Species||Product Description|
|LG9-H5244||Human||Human Galectin-9 / LGALS9 Protein|
Galectin-9 / LGALS9 Molecule Background
Galectin-9 (LGALS9) is also known as tumor antigen HOM-HD-21 and ecalectin. Galectins are a family of proteins defined by their binding specificity for β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. As for Galectin-9, it has high affinity for the Forssman pentasaccharide, and it is also the ligand for HAVCR2/TIM3. Forthermore, Galectin-9 stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth.
- (1) Tuereci O., et al., 1997, J. Biol. Chem. 272:6416-6422.
- (2) Dai S.Y., et al.,2005, J. Immunol. 175:2974-2981.