IFN-beta Molecule Synonym Name
IFN-beta Protein Products
|Cat No||Species||Product Description|
|IFB-H421y||Mouse||ActiveMax® Recombinant Mouse IFN-beta / IFNB1|
IFN-beta Molecule Background
Human type I interferons (IFNs) are a large subgroup of interferon proteins that help regulate the activity of the immune system. Interferons bind to interferon receptors. All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α receptor (IFNAR) that consists of IFNAR1 and IFNAR2 chains. The IFN-β proteins are produced in large quantities by fibroblasts. They have antiviral activity that is involved mainly in innate immune response. Two types of IFN-β have been described, IFN-β1 (IFNB1) and IFN-β3 (IFNB3) (a gene designated IFN-β2 is actually IL-6). IFN-β1 is used as a treatment for multiple sclerosis as it reduces the relapse rate. Furthermore, IFN-β1 can bind to a IFNAR1-IFNAR2 heterodimeric receptor, and can also function with IFNAR1 alone and independently of Jak-STAT pathways.
- (1) de Weerd N.A., et al., 2013, Nat. Immunol. 14:901-907.
- (2) Civas A., et al., 1988, Eur. J. Biochem. 173:311-316.