BTN1A1 / Butyrophilin Molecule
BTN1A1 / Butyrophilin Molecule Synonym Name
BTN1A1 / Butyrophilin Protein Products
|Cat No||Species||Product Description|
|BT1-H5222||Human||Human BTN1A1 / Butyrophilin Protein|
|BT1-H5253||Human||Human BTN1A1 / Butyrophilin Protein, Fc Tag|
BTN1A1 / Butyrophilin Molecule Background
Butyrophilin subfamily 1 member A1 (BTN1A1) is also known as BTN, which is a member of the immunoglobulin superfamily and the major protein associated with fat droplets in the milk. BTN1A1 may have a cell surface receptor function. The human butyrophilin gene is localized in the major histocompatibility complex (MHC) class I region of 6p and may have arisen relatively recently in evolution by the shuffling of exons between 2 ancestral gene families. Furthermore, BTN1A1 regulates the amount of lipids and size of droplets expressed in milk and inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.
- (1) Taylor M.R., et al., 1996, Biochim. Biophys. Acta 1306:1-4.
- (2) Mather IH., et al., 1993, J. Dairy Sci. 76 (12): 3832–50.