BTN3A1 / CD277 Molecule
BTN3A1 / CD277 Molecule Synonym Name
BTN3A1 / CD277 Protein Products
|Cat No||Species||Product Description|
|BT1-H5255||Human||Human BTN3A1 / CD277 Protein, Fc Tag|
BTN3A1 / CD277 Molecule Background
Butyrophilin subfamily 3 member A1 (BTN3A1) is also known as CD277 and BTF5, which belongs to the immunoglobulin superfamily and contains one B30.2/SPRY domain and two Ig-like V-type (immunoglobulin-like) domains. BTN3A1 plays a role in T-cell activation and in the adaptive immune response. Also, BTN3A1 regulates the proliferation of activated T-cells and the release of cytokines and IFNG by activated T-cells. Furthermore, BTN3A1 mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.
- (1) Yamashiro H., et al., 2010, J. Leukoc. Biol. 88:757-767.
- (2) Messal N., et al., 2011, Eur. J. Immunol. 41:3443-3454.
- (3) Harly C., et al., 2012, Blood 120:2269-2279.