Thymopoietin / TMPO Molecule
Thymopoietin / TMPO Molecule Synonym Name
Thymopoietin / TMPO Protein Products
|Cat No||Species||Product Description|
|TMO-H5129||Human||Human Thymopoietin / TMPO Protein|
Thymopoietin / TMPO Molecule Background
Lamina-associated polypeptide 2, isoforms beta/gamma (LAP2) is also known as thymopoietin (TMPO), isoforms beta/gamma (TP beta/gamma). The thymopoetin (TMPO) gene encodes three alternatively spliced mRNAs encoding proteins of 75 kDa (alpha), 51 kDa (beta) and 39 kDa (gamma) which are ubiquitously expressed in all cells. TMPO may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. Also, TMPO may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Furthermore, TMPO beta is a human homolog of the murine protein LAP2. Given the nuclear localization of the three TMPO isoforms, it is unlikely that these proteins play any role in CD90 induction.
- (1) Shaklai S., et al., 2008, Eur. J. Cell Biol. 87:267-278.
- (2) Martins S., et al., 2003, J. Cell Biol. 160:177-188.