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GPC3 proteins from ACROBiosystems
Release time: 2017-11-19 Source: ACROBiosystems Read: 3375

Glypican-3 (GPC3), a 70 kDa surface-bound proteoglycan, is an important biomarker of hepatocellular carcinoma (HCC) (Nakatsura et al., 2003). In the disease tissue, GPC3 is overexpressed at both gene and protein levels. It regulates multiple downstream signaling cascade, and by doing so stimulates macrophage engagement and promotes epithelial-mesenchymal transition (EMT). Therefore, GPC3 has been extensively investigated as a molecule of interest for molecular imaging and targeted therapy.

ACROBiosystems provides a comprehensive panel of human GPC3 proteins, including both His-tagged GPC3 (Cat. No. GP3-H5223) and Fc-fusion GPC3 (Cat. No. GP3-H5258). In addition, we also offer Cynomolgus GPC3 and Mouse GPC3 proteins in His-tagged and Fc-tagged format. The pre-biotinylated GPC3 protein (Avitag™) will come soon.

The interaction between GPC3 and growth factors (Zhou et al., 2017).

GPC3 Highlight


Human Glypican 3 / GPC3, Fc Tag, low endotoxin on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.


Immobilized Human FGF basic, Tag Free (Cat. No. BFF-H4117) at 2 μg/mL (100 μL/well) can bind Human Glypican 3, Fc Tag (Cat. No. GP3-H5258) with a linear range of 0.48-7.8 ng/mL (QC tested).

GPC3 product list

Cat. No. Species Product Descriptio0n
Coming soon Human Biotinylated Human Glypican 3 / GPC3 Protein (Avitag )
GP3-H5258 Human Human Glypican 3 / GPC3 Protein, Fc Tag,low endotoxin
GP3-H5223 Human Human Glypican 3 / GPC3 Protein,low endotoxin
GP3-C5256 Cynomolgus Cynomolgus Glypican 3 / GPC3 Protein,Fc Tag
GP3-C5225 Cynomolgus Cynomolgus Glypican 3 / GPC3 Protein
GP3-M5254 Mouse Mouse Glypican 3 / GPC3 Protein, Fc Tag
GP3-M52H3 Mouse Mouse Glypican 3 / GPC3 Protein
> Click to view all GPC3 products

Related products

Molecule Cat. No. Product Descriptio0n
TGF-Beta 1 TG1-H524x Human Latent TGF-beta 1 / TGFB1 Protein
TGF-Beta 1 TG1-H4212 Human TGF-Beta 1 / TGFB1 Protein
TGF-Beta 1 LAP-H5245 Human LAP (TGF-beta 1) Protein
TGF-Beta 1 TG2-H5252 Human TGF-beta RII / TGFBR2 Protein, Fc Tag
BMP-2 BM2-H4117 Human BMP-2 Protein, Tag Free
BMPR-IA AL3-H5228 Human BMPR-IA / ALK-3 Protein
BMPR-IA AL3-H5259 Human BMPR-IA / ALK-3 Protein, Fc Tag


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