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TIGIT Signaling Axis

TIGIT (T cell immununo receptor with lg and ITIM domains) is a newly discovered immune checkpoint protein expressed on T cells and Natural Killer cells (NK). TIGIT is an inhibitory receptor which modulates the immune activity by competing with activating receptor CD226 (also known as DNAM-1) for ligand binding. This on and off switch of TIGIT & DNAM-1 parallels that of CTLA4 & CD28, which makes it a promising target for anti-tumor therapy.

TIGIT proteins

CD155 (PVR) and CD112 (PVRL2 or Nectin-2) are co-ligands of TIGIT and DNAM-1, while CD113 (PVRL3 or Nectin-3) is only binding to TIGIT. The affinity between different ligands and receptors vary. The binding between TIGIT and CD155 is more robust than that between TIGIT and CD112 or CD113.

ACROBiosystems carries a large collection of recombinant proteins from TIGIT signaling axis. In addition to the commonly used his and Fc tagged proteins, we also carry multiple pre-biotinylated proteins such as Biotinylated Human TIGIT, Avi Tag (Avitag™) (Cat. No. TIT-H82E5), Biotinylated Human CD155 / PVR Protein, Fc Tag, Avi Tag (Avitag™) (Cat. No. CD5-H82F6) and Biotinylated Human Nectin-2 / CD112 Protein, Fc Tag, Avi Tag (Avitag™) (Cat. No. CD2-H82F8). Please find detailed information below:

Product Highlight

biotinylated human TIGIT
Immobilized Human CD155, Fc Tag (Cat. No. CD5-H5251) at 10μg/mL (100 μL/well) can bind Biotinylated Human TIGIT, His Tag (Cat. No. TIT-H82E5) with a linear range of 0.08-0.31 μg/mL (QC tested).

TIGIT Product List

Cat. No.SpeciesProduct DescriptionStructurePurityFeatures
TIT-H82E5
(Biotin-labeled)

Biotinylated Human TIGIT Protein, Avi TagTIT-H82E5

TIT-H82F1
(Biotin-labeled)

Biotinylated Human TIGIT Protein, Fc Tag, Avi TagTIT-H82F1

TIT-C5223
Cynomolgus / Rhesus macaque TIGIT ProteinTIT-C5223-STC1

TIT-C5254
Cynomolgus / Rhesus macaque TIGIT Protein, Fc TagTIT-C5254-STC1

TIT-M52E6
Mouse TIGIT ProteinTIT-M52E6-STC1
TIT-M5257
Mouse TIGIT Protein, Fc TagTIT-M5257-STC1

TIT-R5258
Rat TIGIT Protein, Fc TagTIT-R5258-STC1

TIT-R5259
Rabbit TIGIT Protein, Fc TagTIT-R5259-STC1

TIT-H52H3
Human TIGIT ProteinTIT-H52H3-STC1

TIT-H5253
Human TIGIT Protein, Mouse IgG2a Fc Tag, low endotoxinTIT-H5253-STC1

TIT-H5254
Human TIGIT Protein, Fc TagTIT-H5254-STC1

Other Relevant Products

MoleculeSpeciesCat. No.Product DescriptionStructurePurityFeatures
CD155CD5-H82F6
Biotinylated Human CD155 / PVR Protein, Fc, Avi TagCD5-H82F6-STC1

CD112CD2-H82F8
Biotinylated Human Nectin-2 / CD112 Protein, Fc, Avi TagCD2-H82F8-STC1

CD113PV3-H82F3
Biotinylated Human Nectin-3 / CD113 Protein, Fc, Avi TagPV3-H82F3-STC1

DNAM-1DN1-H82F9
Biotinylated Human DNAM-1 / CD226 Protein, Fc, Avi TagDN1-H82F9-STC1

> Click to view all CD155 products
> Click to view all CD112 products
> Click to view all CD113 products
> Click to view all DNAM-1 products

References

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