>TIGIT Signaling Axis
TIGIT (T cell immununo receptor with lg and ITIM domains) is a newly discovered immune checkpoint protein expressed on T cells and Natural Killer cells (NK). TIGIT is an inhibitory receptor which modulates the immune activity by competing with activating receptor CD226 (also known as DNAM-1) for ligand binding. This on and off switch of TIGIT & DNAM-1 parallels that of CTLA4 & CD28, which makes it a promising target for anti-tumor therapy.
CD155 (PVR) and CD112 (PVRL2 or Nectin-2) are co-ligands of TIGIT and DNAM-1, while CD113 (PVRL3 or Nectin-3) is only binding to TIGIT. The affinity between different ligands and receptors vary. The binding between TIGIT and CD155 is more robust than that between TIGIT and CD112 or CD113.
ACROBiosystems carries a large collection of recombinant proteins from TIGIT signaling axis. In addition to the commonly used his and Fc tagged proteins, we also carry multiple pre-biotinylated proteins such as Biotinylated Human TIGIT, Avi Tag (Avitag™) (Cat. No. TIT-H82E5), Biotinylated Human CD155 / PVR Protein, Fc Tag, Avi Tag (Avitag™) (Cat. No. CD5-H82F6) and Biotinylated Human Nectin-2 / CD112 Protein, Fc Tag, Avi Tag (Avitag™) (Cat. No. CD2-H82F8). Please find detailed information below:
|Cat. No.||Species||Product Description||Structure||Purity||Features|
|Biotinylated Human TIGIT Protein, Avi Tag|
|Biotinylated Human TIGIT Protein, Fc Tag, Avi Tag|
|TIT-C5223||Cynomolgus / Rhesus macaque TIGIT Protein|
|TIT-C5254||Cynomolgus / Rhesus macaque TIGIT Protein, Fc Tag|
|TIT-M52E6||Mouse TIGIT Protein|
|TIT-M5257||Mouse TIGIT Protein, Fc Tag|
|TIT-R5258||Rat TIGIT Protein, Fc Tag|
|TIT-R5259||Rabbit TIGIT Protein, Fc Tag|
|TIT-H52H3||Human TIGIT Protein|
|TIT-H5253||Human TIGIT Protein, Mouse IgG2a Fc Tag, low endotoxin|
|TIT-H5254||Human TIGIT Protein, Fc Tag|
|Molecule||Species||Cat. No.||Product Description||Structure||Purity||Features|
|CD155||CD5-H82F6||Biotinylated Human CD155 / PVR Protein, Fc, Avi Tag|
|CD112||CD2-H82F8||Biotinylated Human Nectin-2 / CD112 Protein, Fc, Avi Tag|
|CD113||PV3-H82F3||Biotinylated Human Nectin-3 / CD113 Protein, Fc, Avi Tag|
|DNAM-1||DN1-H82F9||Biotinylated Human DNAM-1 / CD226 Protein, Fc, Avi Tag|
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