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TIGIT Signaling Axis

TIGIT (T cell immununo receptor with lg and ITIM domains) is a newly discovered immune checkpoint protein expressed on T cells and Natural Killer cells (NK). TIGIT is an inhibitory receptor which modulates the immune activity by competing with activating receptor CD226 (also known as DNAM-1) for ligand binding. This on and off switch of TIGIT & DNAM-1 parallels that of CTLA4 & CD28, which makes it a promising target for anti-tumor therapy.

TIGIT proteins

CD155 (PVR) and CD112 (PVRL2 or Nectin-2) are co-ligands of TIGIT and DNAM-1, while CD113 (PVRL3 or Nectin-3) is only binding to TIGIT. The affinity between different ligands and receptors vary. The binding between TIGIT and CD155 is more robust than that between TIGIT and CD112 or CD113.

ACROBiosystems carries a large collection of recombinant proteins from TIGIT signaling axis. Please find detailed information below:

Bioactivity Data

Fig.1 FACS assay shows Biotinylated Human TIGIT, Fc,Avitag (Cat. No. TIT-H82F1) can bind to 293T cell overexpressing human CD155. The concentration of TIGIT is 0.03 μg/mL.

Fig.2 FACS assay shows that Human TIGIT, Mouse IgG2a Fc tag, low endotoxin (Cat. No. TIT-H5253) can bind to 293T cell overexpressing human CD155. The concentration of TIGIT used is 0.03 μg/mL.

Fig.3 Anti-hTIGIT antibody captured on CM5 chip via Anti-mouse antibodies surface can bind Human TIGIT, His Tag (Cat. No. TIT-H52H5) with an affinity constant of 1.28 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Fig.4 Serial dilutions of Anti-TIGIT Neutralizing antibody (Catalog # EP131-C04) (1:1 serial dilution, from 5 μg/mL to 0.01μg/mL) was added into TIGIT: Biotinylated CD155 binding reactions. The assay was performed according to the protocol described below. Background was subtracted from data points prior to log transformation and curve fitting (QC tested).

TIGIT Product List

Cat. No. Species Product Description Structure Purity Features

Biotinylated Human TIGIT Protein, Fc Tag, Avi Tag TIT-H82F1

Cynomolgus / Rhesus macaque TIGIT Protein TIT-C5223-STC1

Cynomolgus / Rhesus macaque TIGIT Protein, Fc Tag TIT-C5254-STC1

Mouse TIGIT Protein, His Tag TIT-M52E6-STC1

Mouse TIGIT Protein, Fc Tag TIT-M5257-STC1

Rat TIGIT Protein, Fc Tag TIT-R5258-STC1

Rabbit TIGIT Protein, Fc Tag TIT-R5259-STC1

Human TIGIT Protein, Mouse IgG2a Fc Tag, low endotoxin TIT-H5253-STC1

Human TIGIT Protein, Fc Tag TIT-H5254-STC1

Canine TIGIT Protein, His Tag TIT-C52H7-STC1

Other Relevant Products

Molecule Cat. No. Species Product Description Structure Purity Features
CD155 CD5-H82F6
Biotinylated Human CD155 / PVR Protein, Fc, Avi Tag CD5-H82F6-STC1

Rhesus macaque CD155 / PVR Protein, His Tag CD5-R52H5-STC1

Human CD155 / PVR Protein, Mouse IgG2a Fc Tag, low endotoxin CD5-H5254-STC1

Mouse CD155 / PVR Protein, Mouse IgG2a Fc Tag CD5-M5254-STC1

Biotinylated Human CD155 / PVR Protein, His, Avitag™ CD5-H82E3-STC1

Biotinylated Mouse CD155 / PVR Protein, Fc, Avitag™ CD5-M82F7-STC1

Human CD155 / PVR Protein, Fc Tag CD5-H5251-STC1

Human CD155 / PVR Protein, His Tag CD5-H5223-STC1
CD112 CD2-H82F8
Biotinylated Human Nectin-2 / CD112 Protein, Fc, Avi Tag CD2-H82F8-STC1

Human Nectin-2 / CD112 Protein, Mouse IgG2a Fc Tag CD2-H5257-STC1

Human Nectin-2 / CD112 Protein, Fc Tag PV2-H5253-STC1

Human Nectin-2 / CD112 Protein, His Tag PV2-H52E2-STC1

CD113 PV3-H82F3
Biotinylated Human Nectin-3 / CD113 Protein, Fc, Avi Tag PV3-H82F3-STC1

Human Nectin-3 / CD113 Protein, Fc Tag PV3-H5255-STC1

Human Nectin-3 / CD113 Protein, His Tag PV3-H52E4-STC1

DNAM-1 DN1-H82F9
Biotinylated Human DNAM-1 / CD226 Protein, Fc, Avi Tag DN1-H82F9-STC1

Cynomolgus DNAM-1 / CD226 Protein, His Tag DN1-C52H9-STC1

Human DNAM-1 / CD226 Protein, Fc Tag DN1-H5257-STC1

Human DNAM-1 / CD226 Protein, His Tag DN1-H52H6-STC1

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