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Your Position: Home > News > Full coverage and high quality CD47 protein products -- from ACROBiosystems
Full coverage and high quality CD47 protein products -- from ACROBiosystems
Release time: 2017-11-12 Source: ACROBiosystems Read: 82

CD47,or Integrin-associated protein (IAP), is first discovered in a study aimed  at studying integrin αvβ3. It turned out to be associated in cis with integrin αvβ3 on the cell membrane. Followup studies has established CD47 as the quintessential "marker of self" expressed in all cell types. It's a key regulator of tissue homeostasis, and is also involved in a variety of diseases ranging from atherosclerosis to cancer. CD47 protects the host cells by suppressing phagocytosis. It's well established that cancer cell-expressed CD47 interacts with the NK cell-expressed SIRP family proteins, SIRP alpha and SIRP gamma. By so doing, it protects the cancer cell from being eliminated by the innate immune response.

cd47-gene3.jpg

Given its significant role in pathogenesis of cancer and cardiovascular diseases, there is no surprise that CD47 signaling has been heavily investigated for new targeted therapeutics. ACROBiosystems provides a unique set of CD47-relevant products, including mutilple avi tag pre-biotinylated proteins, for rapid high throughput screening. The following pairs of products can be easily adapted to ELISA, Alphalisa, and MSD platform to screen neutralizing compound.

Suggested Pairs

PairsCat. No.Product DescriptionStructure
Pair 1CD7-H82F6Biotinylated Human CD47, Fc Tag, Avi TagCD7-H82F6-STC1
Pair 1SIA-H5225                    Human SIRP alpha (HPLC-verified)SIA-H5225-STC1
Pair 2CD7-H82E9                    Biotinylated Human CD47, Avi TagCD7-H82E9-STC1
Pair 2SIA-H5251                    Human SIRP alpha, Fc Tag (HPLC-verified)SIA-H5251-STC1
Pair 3CD7-H5227                    Human CD47 ProteinCD7-H5227
Pair 3CDA-H82F2                    Biotinylated Human SIRP alpha, Fc, Avi TagCDA-H82F2-STC1
Immobilized Human SIRP alpha Protein, His Tag (Cat. No. SIA-H5225 ) at 2 μg/mL (100 μL/well) can bind Biotinylated Human CD47 Protein, Fc Tag (Cat. No. CD7-H82F6 ) with a linear range of 8-250 ng/mL.
        >Click to view other biotinylated proteins from ACRO

We also offer mouse Fc tagged CD47 and SIRP alpha in case human Fc-tag interferes with your assay design. These products are uniquely suitable to bind with humanized antibodies.

MoleculeCat. No.Product DescriptionStructure
CD47CD7-H52A5Human CD47, mouse IgG2a Fc Tag, low endotoxinCD7-H52A5-STC1
SIRP alphaSIA-H52A8Human SIRP alpha, mouse IgG1 Fc Tag (HPLC-verified)SIA-H52A8-STC1

In addition, we also provide CD47 from other commonly used experimental animal species.

Cat. No.SpeciesProduct DescriptionStructure
CD7-C5252
CD47 Protein, Fc TagCD7-C5252-STC1
CD7-R5257
CD47 Protein, Fc TagCD7-R5257-STC1
CD7-R5256
CD47 Protein, Fc TagCD7-R5256-STC1
CD7-M5251
CD47 Protein, Fc TagCD7-M5251-STC1
        >Click to view all CD47 products
        >Click to view all SIRP alpha products

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