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Your Position: Home > Antigens & Antibodies for Diagnostic Kit Development

Antigens & Antibodies for Diagnostic Kit Development
 
    Committed to high sensitivity & specificity

 Antigens & Antibodies for Diagnostic kit development – Dedicated to high sensitivity & specificity
Background

The current methods of detecting SARS-CoV-2 infection include nucleic acid detections, antibody detections, and antigen detections. Compared to nucleic acid detections, antibody detections and antigen detections are faster and more convenient. Therefore, they are suitable for scenarios such as rapid screening and instant detection.

The sensitivity and specificity of the serological diagnostic kits are significantly affected by the quality of antigen and antibody reagents. To better support the development of the diagnostic kits, ACROBiosystems has developed a serial of high-quality antigen and antibody reagents. Furthermore, several in vitro diagnostics companies are using ACRO's reagents to develop COVID-19 serological diagnostics products. Among them, Babson Diagnostics, a US diagnostics company, successfully obtained the Emergency Use Authority from FDA and launched their chemiluminescent COVID-19 antibody detection kit employing ACRO's biotin-labeled S1 protein.

Products and applications
Reagents for antigen test

ACROBiosystems has launched matched antibody pairs that are specifically designed and screened for antigen detection kit development, which are suitable for different diagnostic assays, such as chemiluminescent immunoassay, ELISA, gold immunochromatography assay, etc. The sensitivity of the sandwich ELISA can be as low as 12 pg/mL in the verification study using recombinant antigens. In addition, the antibody pairs have been verified using inactivated virus samples. The titer, which was determined using our LFA assay, is as low as 5 TCID50.

Facing increasingly complex mutations, scientists are concerned whether the new mutants could be detected by rapid antigen tests. ACROBiosystems successfully verified that our high-sensitive antibody pair (Cat. No. S1N-M12A1/S1N-M13A1) can detect the latest SARS-CoV-2 variants.

Product list

CategoryCat. No.SpeciesProduct Description
Nucleocapsid proteinNUN-S91MouseAnti-SARS-CoV-2 Nucleocapsid Antibody, Mouse IgG1 (AS91) (Trehalose free)Inquiry
NUN-S92MouseAnti-SARS-CoV-2 Nucleocapsid Antibody, Mouse IgG1 (AS92) (Trehalose free)Inquiry
NUN-S46MouseAnti-SARS-CoV-2 Nucleocapsid Antibody, Mouse IgG1 (AS46) (Trehalose free)Inquiry
NUN-S47MouseAnti-SARS-CoV-2 Nucleocapsid Antibody, Mouse IgG1 (AS47) (Trehalose free)Inquiry
NUN-S57MouseAnti-SARS-CoV-2 Nucleocapsid Antibody, Mouse IgG1 (AS57) (Trehalose free)Inquiry
NUN-S60MouseAnti-SARS-CoV-2 Nucleocapsid Antibody, Mouse IgG1 (AS60) (Trehalose free)Inquiry
NUN-S61MouseAnti-SARS-CoV-2 Nucleocapsid Antibody, Mouse IgG1 (AS61) (Trehalose free)Inquiry
S1 proteinS1N-M12A1MouseAnti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (AM122) (Trehalose free)HOTInquiry
S1N-M13A1MouseAnti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (AM130) (Trehalose free)HOTInquiry
S1N-S58MouseAnti-SARS-CoV-2 Spike S1 Antibody, Mouse IgG1 (AS58) (Trehalose free)Inquiry
S1N-S59MouseAnti-SARS-CoV-2 Spike S1 Antibody, Mouse IgG1 (AS59) (Trehalose free)Inquiry

These antibodies were recommended for antigen detection by double antibody sandwich.

>>>  Virus lysis buffer (Cat.No. LY-13) is available for antigen detection kit development.
       >>>  If you have any bulk order inquiry, please feel free to click here.

Assay data

Verification study using inactivated virus

The titer is as low as 5 TCID50 in the verification study using inactivated virus.

Detect RBD mutants with high sensitivity

Detection of SARS-CoV-2 S protein RBD mutants (Cat.No. SPD-C52Hn, SRD-C52H3, SPD-C52Hp)by Sandwich ELISA

Detect SARS-CoV-2 antigen with high specificity

Demonstration of the specificity of Anti-SARS-CoV-2 N antibody pairs (Cat. No. NUN-S46 & Cat. No. NUN-S47) to the Nucleocapsid protein.

High batch-to-batch consistency

Demonstration of the Batch to Batch Consistency of Anti-SARS-CoV-2 Spike S1 Antibody, Chimeric Mab (Cat. No. S1N-M122) to the S1 protein.

Reagents for neutralizing antibody

Testing the levels of neutralizing antibodies against S protein in serum samples is critical in determining the efficacy of vaccines as well as a diagnostic measure of past infections. With the beginning of large-scale immunization with multiple vaccines and the rise of mutant variants, close monitoring of neutralizing antibodies in population and the impact of virus mutation is necessary for effective immunization campaign.        ACROBiosystems has developed multiple high quality RBD proteins and ACE2 proteins to support neutralizing antibody test development.

ACROBiosystems has developed multiple high quality RBD proteins and ACE2 proteins to support neutralizing antibody test development.

Product list

CategoryCat. No.Product description
ACE2 proteinAC2-H5255Human ACE2 / ACEH Protein, Fc Tag (MALS verified)Inquiry
AC2-H82E7Biotinylated Human ACE2 / ACEH Protein, His,Avitag™Inquiry
RBD proteinSPD-C5251SARS-CoV-2 (COVID-19) S protein RBD, Mouse IgG2a Fc TagInquiry
SPD-C5255SARS-CoV-2 (COVID-19) S protein RBD, Fc Tag (MALS verified)Inquiry
SPD-C52M5SARS-CoV-2 S protein RBD trimer, His Tag (MALS verified)Inquiry
Neutralizing antibodyS1N-M12A1Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122) (Trehalose free)Inquiry
SPD-M180Anti-SARS-CoV-2 RBD Potent Neutralizing Antibody, Human IgG1 (AM180)Inquiry
SPD-M128Anti-SARS-CoV-2 RBD Potent Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM128)Inquiry

Assay data

ACROBiosystems has successfully developed a ready-to-use neutralizing antibody titer serologic assay kit (Cat.No. TAS-K022), which showed High correlation with FDA EUA approved ELISA kit, base on our own high quality reagents.

Correlation of TAS-K022 and FDA EUA approved ELISA kit (detecting the serum of after the vaccination)

Reagents of IgG/IgM antibody

ACROBiosystems has designed Spike and Nucleocapsid antigens specifically for diagnostic kits development. The antigens are customizable and bulk order is available. They are perfect for different antibody detection methods, such as chemiluminescent immunoassay, ELISA, gold immunochromatography assay, etc.

Product list

MoleculeCat. No.HostTagRecommended applicationRecommended method
S proteinSPN-C52H7HEK293His TagDetect IgG/IgM by capture methodELISA
GICA
CLIA
Inquiry
S1 protienS1N-C52H2HEK293His TagDetect IgG/IgM by capture methodInquiry
S1N-C82E9HEK293His,Avi tag™Detect IgG/IgM by capture methodInquiry
S2 proteinS2N-C52H2HEK293His TagDetect IgG/IgM by capture methodInquiry
RBD proteinSPD-C52H1HEK293His TagDetect total antibodies by double antigen sandwich method (detection)Inquiry
SPD-C52H2HEK293His TagDetect IgG/IgM by capture methodInquiry
SPD-C5251HEK293Mouse Fc TagDetect total antibodies by double antigen sandwich method (capture)Inquiry
SPD-C82E8HEK293His,Avi tag™Detect IgG/IgM by capture methodInquiry
Nucleocapsid proteinNUN-C5221HEK293His TagDetect IgG/IgM by capture methodInquiry
NUN-C51H2E.coliHis TagDetect IgG/IgM by capture methodInquiry
NUN-C81Q8E.coliHis,Avi tag™Detect IgG/IgM by capture methodInquiry

>>>  If you have any bulk order inquiry, please feel free to click here.

>>>  If you have any custom inquiries or suggestions for SARS-CoV-2 (COVID-19) related products, please click here.

IgG/IgM control antibodies are available for antibody detection kit development.

Cat. No.SpeciesProduct DescriptionSubtypeMolecule
S1N-M122MouseAnti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb (AM122)Human IgG1S protein RBDInquiry
SPD-M180HumanAnti-SARS-CoV-2 RBD Potent Neutralizing Antibody (AM180)Human IgG1S protein RBDInquiry
SAD-S35HumanAnti-SARS-CoV-2 Spike RBD Neutralizing Antibody (AS35)Human IgG1S protein RBDInquiry
SPD-M128MouseAnti-SARS-CoV-2 RBD Potent Neutralizing Antibody, Chimeric mAb (AM128)Human IgG1S protein RBDInquiry
S1N-M130MouseAnti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb (AM130)Human IgG1S protein RBDInquiry
SPD-M121MouseAnti-SARS-CoV-2 Spike NTD Neutralizing Antibody, Chimeric mAb (AM121)Human IgG1S1 protein NTDInquiry
SPD-M162MouseAnti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb (AM122)Human IgMS protein RBDInquiry
S2N-S86HumanAnti-SARS-CoV-2 Spike S2 Antibody (AS86)Human IgG4S2 proteinInquiry

Assay data

High sensitivity of 0.02 ng/mL (ELISA assay)

Immobilized SARS-CoV-2 Nucleocapsid protein, His Tag at 2 μg/mL (100 μL/well) can bind SARS-CoV-2 NP Antibody, Rabbit MAb (CLN27) with a linear range of 0.02-0.3 ng/mL.

>>> All SARS-CoV-2 related products

>>> SARS-CoV-2 related kits

>>> Reagent for vaccine development and evaluation

>>> Any custom requests, suggestions or feedback are welcome.Click here.

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