BCMA is selectively induced during plasma cell differentiation and is nearly absent on naive and memory B cells (Avery et al., 2003; Chiu et al., 2007). The interaction between BCMA and its ligand BAFF and APRIL is involved for the maintenance of long-lived plasma cells (O'Connor et al., 2004; Peperzak et al., 2013). Multiple BCMA-targeted therapies of B-cell derived malignancies are underdevelopment, including BCMA-targeting chimeric antigen receptor T (CAR-T) and GlaxoSmithKline's GSK2857916.
Selective interaction between BAFF/APRIL and their receptors. Note BCMA can interact with both BAFF and APRIL (Bolkun et al., 2016). The affinity of APRIL-BCMA interaction, however, is much higher than that of BAFF-BCMA binding (Bossen and Schneider, 2006).
ACROBiosystems provides a comprehensive panel of BCMA proteins, including the exclusive biotinylated BCMA (Cat. No. BCA-C82F4) and the monomeric BCMA (Cat. No. BCA-H522y). We also offer BCMA related proteins, such as BAFF and BAFFR proteins.
The binding activity of our BCMA and BAFF proteins have been thoroughly evaluated by ELISA analyses prior to launch.
Immobilized Human BAFF, Fc Tag at 5μg/mL (100 μL/well) can bind Biotinylated Human BCMA, Fc Tag (Cat. No. BC7-H82F0) with a linear range of 0.12-1.95 ng/mL.
The production of our recombinant proteins including BCMA proteins is carried out using our proprietary HEKMax® expression platform. Proteins retain their authentic post-translational processing, which often translates into high bioactivity and stability.
We offer a variety of ready-to-use biotinylated proteins using our in-house developed labeling techniques, which confer high bioactivity and minimal batch-to-batch variation. In addition, we also offer FITC-Labeled BCMA and BAFF proteins.
|Molecule||Cat. No||Product Description||Structure|
|BCMA||BC7-H82F0||Biotinylated Human BCMA / TNFRSF17 Protein, Fc Tag, Avi Tag (Avitag™)|
|BCMA||BCA-H522y||Human BCMA / TNFRSF17 Protein|
|BCMA||BCA-HF254||FITC-Labeled Human BCMA / TNFRSF17Protein, Fc Tag|
|BCMA||BC7-H5254||Human BCMA / TNFRSF17 Protein, Fc Tag|
|BCMA||BCA-C82F4||Biotinylated Cynomolgus BCMA / TNFSF17 Protein, Fc Tag, Avi Tag (Avitag™)|
|BAFF||BAF-H82F3||Biotinylated Human BAFF / TNFSF13B / CD257 Protein, Fc Tag, Avi Tag (Avitag™), Avi Tag (Avitag™)|
|BAFF||BAF-HF268||FITC-Labeled Human BAFF / TNFSF13B / CD257 Protein, Fc Tag|
|BAFF||BAF-H82Q2||Biotinylated Human BAFF / TNFSF13B / CD257 Protein, Avi Tag (Avitag™),Avi Tag (Avitag™)|
|BAFFR||BAR-M82F0||Biotinylated Mouse BAFFR /TNFRSF13C Protein, Fc Tag,Avi Tag (Avitag™)|
|BAFFR||BAR-M5259||Mouse BAFFR / TNFRSF13C Protein, Fc Tag|
|BAFFR||BAR-H5257||Human BAFFR / TNFRSF13C Protein, Fc Tag|
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