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Your Position: Home > Newsletter > A Comprehensive Panel of BCMA/ BAFF/ BAFFR Proteins
A Comprehensive Panel of BCMA/ BAFF/ BAFFR Proteins
Release time: 2017-03-09 Source: ACROBiosystems Read: 895

BCMA is selectively induced during plasma cell differentiation and is nearly absent on naive and memory B cells (Avery et al., 2003; Chiu et al., 2007). The interaction between BCMA and its ligand BAFF and APRIL is involved for the maintenance of long-lived plasma cells (O'Connor et al., 2004; Peperzak et al., 2013). Multiple BCMA-targeted therapies of B-cell derived malignancies are underdevelopment, including BCMA-targeting chimeric antigen receptor T (CAR-T) and GlaxoSmithKline's GSK2857916.

BCMA

Selective interaction between BAFF/APRIL and their receptors. Note BCMA can interact with both BAFF and APRIL (Bolkun et al., 2016). The affinity of APRIL-BCMA interaction, however, is much higher than that of BAFF-BCMA binding (Bossen and Schneider, 2006).

ACROBiosystems provides a comprehensive panel of BCMA proteins, including the exclusive biotinylated BCMA (Cat. No. BCA-C82F4) and the monomeric BCMA (Cat. No. BCA-H522y). We also offer BCMA related proteins, such as BAFF and BAFFR proteins.

Why Choose Us

Bioactivity Validated in Functional ELISA

The binding activity of our BCMA and BAFF proteins have been thoroughly evaluated by ELISA analyses prior to launch.

BC7-H82F0

Immobilized Human BAFF, Fc Tag (Cat. No. BAF-H4268) at 5μg/mL (100 μL/well) can bind Biotinylated Human BCMA, Fc Tag (Cat. No. BC7-H82F0) with a linear range of 0.12-1.95 ng/mL.

Authentic Human Cell-Expressed Proteins

The production of our recombinant proteins including BCMA proteins is carried out using our proprietary HEKMax® expression platform. Proteins retain their authentic post-translational processing, which often translates into high bioactivity and stability.

Biotin-Labeled & FITC-Labeled Proteins Available

We offer a variety of ready-to-use biotinylated proteins using our in-house developed labeling techniques, which confer high bioactivity and minimal batch-to-batch variation. In addition, we also offer FITC-Labeled BCMA and BAFF proteins.

Product List

MoleculeCat. NoProduct DescriptionStructure
BCMABC7-H82F0Biotinylated Human BCMA / TNFRSF17 Protein, Fc Tag, Avi Tag (Avitag™)
BCMABCA-H522yHuman BCMA / TNFRSF17 Protein
BCMABCA-HF254FITC-Labeled Human BCMA / TNFRSF17Protein, Fc Tag
BCMABC7-H5254Human BCMA / TNFRSF17 Protein, Fc Tag
BCMABCA-C82F4Biotinylated Cynomolgus BCMA / TNFSF17 Protein, Fc Tag, Avi Tag (Avitag™)
BAFFBAF-H4218Human BAFF / TNFSF13B / CD257 Protein, Tag Free
BAFFBAF-H4268Human BAFF / TNFSF13B / CD257 Protein, Fc Tag
BAFFBAF-H5248Human BAFF / TNFSF13B / CD257 Protein
BAFFBAF-H82F3Biotinylated Human BAFF / TNFSF13B / CD257 Protein, Fc Tag, Avi Tag (Avitag™), Avi Tag (Avitag™)
BAFFBAF-HF268FITC-Labeled Human BAFF / TNFSF13B / CD257 Protein, Fc Tag
BAFFBAF-H82Q2Biotinylated Human BAFF / TNFSF13B / CD257 Protein, Avi Tag (Avitag™),Avi Tag (Avitag™)
BAFFRBAR-M82F0Biotinylated Mouse BAFFR /TNFRSF13C Protein, Fc Tag,Avi Tag (Avitag™)
BAFFRBAR-M5259Mouse BAFFR / TNFRSF13C Protein, Fc Tag
BAFFRBAR-H5257Human BAFFR / TNFRSF13C Protein, Fc Tag

References

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